A ground-breaking finding discovered by researchers searching for a cancer cure may turn certain cancer cells into healthy cells.
The body gets cancer when a cell’s DNA changes, turning it from a normal cell to a malignant one and leading it to grow out of control.
Age, injury (from sun exposure, for example), or inheritance can all cause mutations.
The ability to transform a cancerous cell back into something more like normal is a hugely important development because it may lessen the unpleasant side effects of some commonly used cancer treatments, like chemotherapy and radiation, in addition to opening up a new treatment option for some cancers.
This is due to the fact that rather than being totally destroyed, the cell is being brought back to a state that is similar to normal.
The study was conducted under the direction of Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering at the Korean Advanced Institute of Science and Technology.
Colon cancer cells were effectively transformed into a normal state by Professor Kwang-Hyun Cho and his research team using a digital model of normal cell development.
The oncogenesis process, which happens when healthy cells change into cancerous cells, was observed by the scientists during the investigation.
They found that substances called master regulators (MYB, HDAC2, and FOXA2) caused differentiation after building a digital duplicate of the gene network.
According to the study, which was published in Advanced Science, enterocyte differentiation is induced by the suppression of master regulators MYB, HDAC2, and FOXA2.
By cooperatively promoting differentiation and inhibiting malignancy, it has been discovered that simultaneous knockdown of these master regulators can transform colorectal cancer cells back into normal-like enterocytes.
Experiments on mice with malignant tumors were subsequently used to validate the findings of the digital study.
Regarding the discovery, Professor Kwang-Hyun Cho said: It is a remarkable phenomena that cancer cells can be transformed back into healthy cells.
This work illustrates the methodical induction of such reversion.
By turning cancer cells into healthy ones, this study presents the innovative idea of reversible cancer therapy.
By methodically examining the pathways of normal cell differentiation, it also develops the basic technologies for determining targets for cancer reversion.
The findings offered novel opportunities for the application of reversible cancer therapy in different cancer treatments.
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